Artefill – (FDA approved 10/2006)

    Artefill is a non-absorbable injectable dermal filler used for the correction of wrinkles and lines on the face. Artefill is approved by the FDA for correctıng smile lines (nasolabial folds) but it is widely used “off label” by physicians to fill lines and wrinkles all over the face. It is a formulation of medical grade polymethylmethacrylate (PMMA) microspheres and bovine collagen along with lidocaine and buffers. The PMMA microspheres in Artefill are not absorbed by the body and therefore provide permanent support for wrinkle correction. Due to the fact that this product contains animal (cow) derived collagen patients must be skin tested for possible allergic reactions.

    Medical grade PMMA has been used for decades in a variety of medical applications including intraocular lenses to treat cataracts, artificial joints, etc. PMMA microspheres have been used for cosmetic soft tissue augmentation outside of the USA in an estimated 200,000 procedures over the past 10 years. Artefill is injected underneath the wrinkle, just above the skin’s fat layer. Most patients require 1 or 2 treatments, depending on the depth of their wrinkles and folds.

    The most common adverse events associated with Artefill treatment are similar to those observed with other dermal fillers, and side effects usually resolve within 24 hours. Less common side effects include rash and itching, persistent swelling or redness, and increased sensitivity at injection sites.